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Cavernous sinus thrombosis (CST) is a thrombus formation within the cavernous sinus, which may be either septic or aseptic in origin. Infection can spread to the cavernous sinus either as an extension of thrombophlebitis or by septic emboli. The origin of aseptic cavernous sinus thrombosis is usually through trauma or a prothrombotic condition.\n\nIn the pre-antibiotic era, infections of the middle third of the face were responsible for the majority of cases. Currently, acute sinusitis is the most common predisposing condition.\n\nDiagnosis is usually made through clinical evaluation together with imaging (computed tomography or magnetic resonance imaging).\n\nIn the acute presentation, one eye is typically affected first, followed by the second eye within 48 hours of symptom onset.\n\nMust be differentiated from meningitis. Common early clinical features of both conditions include fever, headache, vomiting, and nuchal rigidity.\n\nAntibiotics should be started immediately because they have the

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